Moderators
Sonia Fieulaine (I2BC, Gif-sur-Yvette)
Jean-Denis Pedelaq (IPBS, Toulouse)
Summary
Structural biology plays a central role in our understanding of the molecular mechanisms of life. Easier access to synchrotron sources for X-ray experiments and advances in cryo-electron microscopy now make it possible to accurately characterise the three-dimensional structures of macromolecules, whether isolated or interacting with other partners. When combined with molecular modelling and in silico screening approaches, this provides a powerful methodological framework for rational drug design and optimising ligand-target interactions.